Increased expression levels of p53 correlate with good response to cisplatin-based chemotherapy in non-small cell lung cancer.

@article{Oshita2000IncreasedEL,
  title={Increased expression levels of p53 correlate with good response to cisplatin-based chemotherapy in non-small cell lung cancer.},
  author={Fumihiro Oshita and Kazuto Nishio and Yoichi Kameda and Aki Mitsuda and Mizuki Ikehara and Gaku Tanaka and Kouzo Yamada and Ikuo Nomura and Kazumasa Noda and Hiromasa Arai and Hiroshi Ito and Hirofumi Nakayama},
  journal={Oncology reports},
  year={2000},
  volume={7 6},
  pages={
          1225-8
        }
}
In order to determine whether expression of the tumor suppressor gene p53 in non-small cell lung cancer (NSCLC) correlates with chemotherapeutic response, resected tumors from 18 patients with recurrent lung cancer who had undergone complete resection and received chemotherapy after the initial tumor recurrence were subjected to p53 immunostaining. Histological examination of the resected tumors revealed 11 adenocarcinomas, 6 squamous cell carcinomas and one adenosquamous cell carcinoma. Group… CONTINUE READING