• DOI:10.1016/J.NBD.2005.06.017
Corpus ID: 17817187

Increased expression and function of glutamate transporters in multiple sclerosis

@article{VallejoIllarramendi2006IncreasedEA,
  title={Increased expression and function of glutamate transporters in multiple sclerosis},
  author={A. Vallejo-Illarramendi and M. Domercq and F. P{\'e}rez-Cerd{\'a} and R. Ravid and C. Matute},
  journal={Neurobiology of Disease},
  year={2006},
  volume={21},
  pages={154-164}
}

A. Vallejo-Illarramendi, M. Domercq, +2 authors C. Matute

Published 2006

Chemistry, Medicine

Neurobiology of Disease

Recent studies have shown that glutamate excitotoxicity may be a component in the etiology of multiple sclerosis (MS). Glutamate transporters determine the levels of extracellular glutamate and are essential to prevent excitotoxicity. We have analyzed here the expression of the glutamate transporters EAAT1, EAAT2 and EAAT3 in control and in MS optic nerve samples. We observed an overall increase in the level of the glutamate transporters EAAT1 and EAAT2 mRNA and protein. In turn, functional… CONTINUE READING

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