Increased expression and function of glutamate transporters in multiple sclerosis

  title={Increased expression and function of glutamate transporters in multiple sclerosis},
  author={A. Vallejo-Illarramendi and M. Domercq and F. P{\'e}rez-Cerd{\'a} and R. Ravid and C. Matute},
  journal={Neurobiology of Disease},
  • A. Vallejo-Illarramendi, M. Domercq, +2 authors C. Matute
  • Published 2006
  • Chemistry, Medicine
  • Neurobiology of Disease
  • Recent studies have shown that glutamate excitotoxicity may be a component in the etiology of multiple sclerosis (MS). Glutamate transporters determine the levels of extracellular glutamate and are essential to prevent excitotoxicity. We have analyzed here the expression of the glutamate transporters EAAT1, EAAT2 and EAAT3 in control and in MS optic nerve samples. We observed an overall increase in the level of the glutamate transporters EAAT1 and EAAT2 mRNA and protein. In turn, functional… CONTINUE READING
    123 Citations

    Figures, Tables, and Topics from this paper

    Increased expression of cystine/glutamate antiporter in multiple sclerosis
    • 81
    • PDF
    The role of glutamate and its receptors in multiple sclerosis
    • 53
    Glutamate Transporters: Expression and Function in Oligodendrocytes
    • 4
    Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System
    • 21
    • Highly Influenced
    • PDF
    The Regulation of Astrocytic Glutamate Transporters in Health and Neurodegenerative Diseases
    • PDF
    Glutamate Receptor Expression in Multiple Sclerosis Lesions
    • 142
    Regional regulation of glutamate signaling during cuprizone-induced demyelination in the brain.
    • 30
    Transporters for L‐glutamate: An update on their molecular pharmacology and pathological involvement
    • 365


    Expression of the glial glutamate transporter EAAT2 in the human CNS: an immunohistochemical study.
    • 115
    Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage
    • 431
    • Highly Influential
    Expression of glutamate transporters in rat optic nerve oligodendrocytes
    • 123
    Expression of excitatory amino acid transporter‐2 (EAAT‐2) and glutamine synthetase (GS) in brain macrophages and microglia of SIVmac251‐infected macaques
    • 74
    Glutamate uptake
    • 2,587
    • Highly Influential
    Glutamate transporters are oxidant-vulnerable: a molecular link between oxidative and excitotoxic neurodegeneration?
    • 455
    Changes of retinal glutamate transporter GLT-1 mRNA levels following optic nerve damage.
    • 27
    • PDF
    Rapid changes in expression of glutamate transporters after spinal cord injury
    • 82
    Glutamate excitotoxicity in a model of multiple sclerosis
    • 779
    • Highly Influential
    • PDF