Increased expression and function of glutamate transporters in multiple sclerosis

@article{VallejoIllarramendi2006IncreasedEA,
  title={Increased expression and function of glutamate transporters in multiple sclerosis},
  author={A. Vallejo-Illarramendi and M. Domercq and F. P{\'e}rez-Cerd{\'a} and R. Ravid and C. Matute},
  journal={Neurobiology of Disease},
  year={2006},
  volume={21},
  pages={154-164}
}
  • A. Vallejo-Illarramendi, M. Domercq, +2 authors C. Matute
  • Published 2006
  • Chemistry, Medicine
  • Neurobiology of Disease
  • Recent studies have shown that glutamate excitotoxicity may be a component in the etiology of multiple sclerosis (MS). Glutamate transporters determine the levels of extracellular glutamate and are essential to prevent excitotoxicity. We have analyzed here the expression of the glutamate transporters EAAT1, EAAT2 and EAAT3 in control and in MS optic nerve samples. We observed an overall increase in the level of the glutamate transporters EAAT1 and EAAT2 mRNA and protein. In turn, functional… CONTINUE READING
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