Increased expression and activation of IL-12-induced Stat4 signaling in the mucosa of ulcerative colitis patients.

@article{Pang2007IncreasedEA,
  title={Increased expression and activation of IL-12-induced Stat4 signaling in the mucosa of ulcerative colitis patients.},
  author={Yan Hua Pang and Chang Qing Zheng and Xian Zi Yang and Wen Zhang},
  journal={Cellular immunology},
  year={2007},
  volume={248 2},
  pages={
          115-20
        }
}
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory diseases with unsolved pathogenesis. Imbalanced Th1/Th2 may play a role in the sustained inflammation of IBD. In China, CD is rare but the incidence of UC has been rising steadily in the last two decades. We investigated the expression of IL-12 (p40) and IFN-gamma, and the activational state of Stat4 signaling in mucosal tissues at the site of disease from 30 active UC… CONTINUE READING
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