Increased excitability in cortico-striatal synaptic pathway in a model of paroxysmal dystonia

@article{Khling2004IncreasedEI,
  title={Increased excitability in cortico-striatal synaptic pathway in a model of paroxysmal dystonia},
  author={R{\"u}diger K{\"o}hling and Uwe-Robert Koch and Melanie Hamann and Angelika Richter},
  journal={Neurobiology of Disease},
  year={2004},
  volume={16},
  pages={236-245}
}
Dystonias are movement disorders whose pathomechanism is largely unknown. Dystonic dt(sz) hamsters represent a model of primary dystonias, where alterations of striatal interneuron density and sodium channel function in projection neurones were described. Here, using cortico-striatal slices, we explore whether also the communication between neocortex and striatum is altered in dt(sz) hamsters. Field and intracellular recordings were done in dorsomedial striatum. Electrical stimulation was used… CONTINUE READING

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