Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex.

@article{Benardete2002IncreasedEA,
  title={Increased excitability and decreased sensitivity to GABA in an animal model of dysplastic cortex.},
  author={Ethan A. Benardete and Arnold R Kriegstein},
  journal={Epilepsia},
  year={2002},
  volume={43 9},
  pages={970-82}
}
PURPOSE Cortical dysplasia (CD) is associated with epilepsy in both the pediatric and adult populations. The mechanism underlying seizures with cortical malformations is still poorly understood. To study the physiology of dysplastic cortex, we developed an experimental model of CD. METHODS Pregnant rats were given intraperitoneal injections of carmustine (1-3-bis-chloroethyl-nitrosourea; BCNU) on embryonic day 15 (E15). Cortical histology was examined in the resulting pups at P0, P28, and P60… CONTINUE READING

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