Increased exchange rate of histone H1 on chromatin by exogenous myogenin expression

@article{Gong2002IncreasedER,
  title={Increased exchange rate of histone H1 on chromatin by exogenous myogenin expression},
  author={Ming Gong and J. H. Ni and Hong T Jia},
  journal={Cell Research},
  year={2002},
  volume={12},
  pages={395-400}
}
ABSTRACTTo explore the molecular mechanism of chromatin remodeling involved in the regulation of transcriptional activation of specific genes by a myogenic regulatory factor Myogenin, we used NIH3T3 fibroblasts with a stably integrated H1.1-GFP fusion protein to monitor histone H1 movement directly by fluorescence recovery after photobleaching (FRAP) in living cells. The observation from FRAP experiments with myogenin transfected fibroblasts showed that the exchange rate of histone H1 in… CONTINUE READING