Increased error-prone non homologous DNA end-joining – a proposed mechanism of chromosomal instability in Bloom's syndrome

@article{Gaymes2002IncreasedEN,
  title={Increased error-prone non homologous DNA end-joining – a proposed mechanism of chromosomal instability in Bloom's syndrome},
  author={Terry J. Gaymes and Phillip S. North and Nicola Brady and Ian D. Hickson and Ghulam J. Mufti and Feyruz V Rassool},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={2525-2533}
}
BS is an inherited cancer predisposition disorder caused by inactivation of the RecQ family helicase, BLM. One of the defining features of cells from BS individuals is chromosomal instability, characterized by elevated sister chromatid exchanges (SCEs), as well as chromosomal breaks, deletions, and rearrangements. Although the basis for chromosomal… CONTINUE READING