Increased endothelin-1 production in patients with chronic heart failure.

@article{Parker2004IncreasedEP,
  title={Increased endothelin-1 production in patients with chronic heart failure.},
  author={John D Parker and Jake J. Thiessen},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={286 3},
  pages={
          H1141-5
        }
}
Endothelin-1 (ET-1) concentrations are elevated in patients with congestive heart failure (CHF), although the cause of this increase remains uncertain. We hypothesized that abnormalities in ET-1 production, clearance, or a combination of these may be the cause of elevated ET-1 concentrations in chronic CHF. The kinetics of clearance of ET-1 were measured with (125)I-labeled ET-1 in eight patients with CHF and five age-matched normal individuals. In both normal subjects and the CHF group, the… CONTINUE READING

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