Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis.

@article{Zakkar2008IncreasedEM,
  title={Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis.},
  author={Mustafa Zakkar and Hera Chaudhury and Gunhild F Sandvik and Karine Enesa and Le Anh Luong and Simon Cuhlmann and J. Christian Mason and Rob Krams and A R Clark and Dorian O. Haskard and Paul C. Evans},
  journal={Circulation research},
  year={2008},
  volume={103 7},
  pages={726-32}
}
Atherosclerosis is a chronic inflammatory disease of arteries. It is triggered by proinflammatory mediators which induce adhesion molecules (eg, vascular cell adhesion molecule [VCAM]-1) in endothelial cells (ECs) by activating p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein (MAP) kinases by phosphorylation. Blood flow influences atherosclerosis by exerting shear stress (mechanical drag) on the inner surface of arteries, a force that alters endothelial physiology. Regions of the… CONTINUE READING
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