Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events

@article{Mullick2008IncreasedEE,
  title={Increased endothelial expression of Toll-like receptor 2 at sites of disturbed blood flow exacerbates early atherogenic events},
  author={Adam E. Mullick and Katrin Soldau and William B. Kiosses and Thomas A. Bell and Peter S. Tobias and Linda K. Curtiss},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={373 - 383}
}
Toll-like receptors (TLRs) are pattern recognition receptors of innate immunity. TLRs initiate inflammatory pathways that may exacerbate chronic inflammatory diseases like atherosclerosis. En face laser scanning confocal microscopy (LSCM) of isolated aortic segments revealed the distribution of intimal TLR2 expression and the atheroprotective outcomes resulting from a TLR2 deficiency. TLR2 expression was restricted to endothelial cells in regions of disturbed blood flow, such as the lesser… CONTINUE READING

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Atherosclerosis – an infl ammatory disease

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