Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection.

@article{Fuchs1991IncreasedEI,
  title={Increased endogenous interferon-gamma and neopterin correlate with increased degradation of tryptophan in human immunodeficiency virus type 1 infection.},
  author={Dietmar Fuchs and Arnulf A. M{\"o}ller and Gilbert Reibnegger and Ernst R Werner and G Werner-felmayer and Manfred Paul Dierich and Helmut Wachter},
  journal={Immunology letters},
  year={1991},
  volume={28 3},
  pages={207-11}
}
Reduced tryptophan and increased kynurenine concentrations have been reported in patients with human immunodeficiency virus type 1 (HIV-1) infection. From in vitro data it appears that activated indoleamine 2,3-dioxygenase (IDO) is involved in this metabolic change. IDO is inducible by interferon-(IFN)-gamma. We compared serum concentrations of IFN-gamma and neopterin (the biosynthesis of which is also inducible by IFN-gamma) with serum, tryptophan and kynurenine of 42 patients with HIV-1… CONTINUE READING