Increased efficacy of μ-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL/6 mice: comparison with (−)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959)

Abstract

Recent experimental data suggest that metabotropic glutamate receptor (mGluR) antagonists with selectivity for mGluR1 and mGluR2/3 enhance morphine-induced antinociception. The present study addressed the hypothesis that mGluR antagonists enhance opioid antinociception by increasing opioid efficacy. The antinociceptive effects of the partial μ-opioid… (More)
DOI: 10.1007/s00213-008-1130-y

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@article{Fischer2008IncreasedEO, title={Increased efficacy of μ-opioid agonist-induced antinociception by metabotropic glutamate receptor antagonists in C57BL/6 mice: comparison with (−)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid (LY235959)}, author={Bradford D. Fischer and Laurence L. Miller and Fredrick E. Henry and Mitchell J. Picker and Linda A. Dykstra}, journal={Psychopharmacology}, year={2008}, volume={198}, pages={271-278} }