Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

@article{Tissenbaum2001IncreasedDO,
  title={Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans},
  author={H. Tissenbaum and L. Guarente},
  journal={Nature},
  year={2001},
  volume={410},
  pages={227-230}
}
  • H. Tissenbaum, L. Guarente
  • Published 2001
  • Medicine, Biology
  • Nature
  • In Caenorhabditis elegans, mutations that reduce the activity of an insulin-like receptor (daf-2) or a phosphatidylinositol-3-OH kinase (age-1) favour entry into the dauer state during larval development and extend lifespan in adults. Downregulation of this pathway activates a forkhead transcription factor (daf-16), which may regulate targets that promote dauer formation in larvae and stress resistance and longevity in adults. In yeast, the SIR2 gene determines the lifespan of mother cells, and… CONTINUE READING

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