Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

@article{Tissenbaum2001IncreasedDO,
  title={Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans},
  author={Heidi A. Tissenbaum and Leonard P Guarente},
  journal={Nature},
  year={2001},
  volume={410},
  pages={227-230}
}
In Caenorhabditis elegans, mutations that reduce the activity of an insulin-like receptor (daf-2) or a phosphatidylinositol-3-OH kinase (age-1) favour entry into the dauer state during larval development and extend lifespan in adults. Downregulation of this pathway activates a forkhead transcription factor (daf-16), which may regulate targets that promote dauer formation in larvae and stress resistance and longevity in adults. In yeast, the SIR2 gene determines the lifespan of mother cells, and… 

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TLDR
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