Increased detection of mammary carcinoma cells in marrow smears using antisera to epithelial membrane antigen.

@article{Dearnaley1981IncreasedDO,
  title={Increased detection of mammary carcinoma cells in marrow smears using antisera to epithelial membrane antigen.},
  author={David P. Dearnaley and John P Sloane and Michael G. Ormerod and Kathleen J. Steele and R C Coombes and HughM. Clink and Trevor J. Powles and Hubert T. Ford and J. C. Gazet and A. Munro Neville},
  journal={British Journal of Cancer},
  year={1981},
  volume={44},
  pages={85 - 90}
}
We have developed a technique for the immunocytochemical staining of marrow smears using antiserum to epithelial membrane antigen (EMA). This membrane component is confined to, but widely distributed in, epithelial tissues and tumours derived from them, and is strongly expressed by infiltrating breast carcinoma cells. Marrow aspirates from patients with both early and metastatic breast cancer have been examined, and the results of immunocytochemical staining compared with conventional cytology… CONTINUE READING
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