Increased dentate gyrus excitability in neuroligin-2-deficient mice in vivo.

@article{Jedlicka2011IncreasedDG,
  title={Increased dentate gyrus excitability in neuroligin-2-deficient mice in vivo.},
  author={Peter Jedlicka and Mrinalini Hoon and Theofilos G. Papadopoulos and Andreas Vlachos and Raphael Winkels and Alexandros Poulopoulos and Heinrich Betz and Thomas Deller and Nils Brose and Frederique Varoqueaux and Stephan W. Schwarzacher},
  journal={Cerebral cortex},
  year={2011},
  volume={21 2},
  pages={357-67}
}
The postsynaptic adhesion protein neuroligin-2 (NL2) is selectively localized at inhibitory synapses. Here, we studied network activity in the dentate gyrus of NL2-deficient mice following perforant path (PP) stimulation in vivo. We found a strong increase in granule cell (GC) excitability. Furthermore, paired-pulse inhibition (PPI) of the population spike, a measure for γ-aminobutyric acid (GABA)ergic network inhibition, was severely impaired and associated with reduced GABA(A) receptor (GABA… CONTINUE READING

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