Increased death receptor resistance and FLIPshort expression in polycythemia vera erythroid precursor cells.

@article{Zeuner2006IncreasedDR,
  title={Increased death receptor resistance and FLIPshort expression in polycythemia vera erythroid precursor cells.},
  author={Ann Zeuner and Francesca Pedini and Michele Signore and Giusy Ruscio and Carlo Messina and Agostino Tafuri and Gabriella Girelli and Cesare Peschle and Ruggero de Maria},
  journal={Blood},
  year={2006},
  volume={107 9},
  pages={
          3495-502
        }
}
Polycythemia vera (PV) is a clonal myeloproliferative disorder characterized by excessive erythrocyte production. Most patients with PV harbor an activating JAK2 mutation, but the molecular links between this mutation and erythrocyte overproduction are unknown. The interaction between death receptors and their ligands contributes to the physiological regulation of erythropoiesis through the inhibition of erythroblast proliferation and differentiation. With the use of an in vitro culture system… CONTINUE READING

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