Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo.

@article{Nagane2000IncreasedDR,
  title={Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo.},
  author={Motoo Nagane and Guohua Pan and Jessie J. Weddle and Vishva M. Dixit and Webster K Cavenee and H. J. Huang},
  journal={Cancer research},
  year={2000},
  volume={60 4},
  pages={847-53}
}
The intractability of malignant gliomas to multimodality treatments plays a large part in their extremely poor prognosis. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a novel member of the tumor necrosis factor (TNF) family that induces apoptosis preferentially in tumor cells through binding to its cognate death receptors, DR4 and DR5… CONTINUE READING