Increased cytosolic pH in multidrug-resistant human lung tumor cells: effect of verapamil.

@article{Keizer1989IncreasedCP,
  title={Increased cytosolic pH in multidrug-resistant human lung tumor cells: effect of verapamil.},
  author={Hiskias G Keizer and Hans Joenje},
  journal={Journal of the National Cancer Institute},
  year={1989},
  volume={81 9},
  pages={706-9}
}
In a set of four increasingly multidrug-resistant variants of SW-1573 human lung tumor cells, the pHi (i.e., steady-state cytosolic pH) increased up to 0.44 U as a function of the level of doxorubicin resistance. The elevated pHi in the most resistant (2,000-fold) variant dropped to the control level upon addition of verapamil, a known inhibitor of P-glycoprotein activity. These data suggest that, in the absence of xenobiotic substrates, P-glycoprotein activity can affect cellular pHi. This… CONTINUE READING

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