Increased cytosolic Ca(2+) concentration in endothelial cells by calmodulin antagonists.

@article{Watanabe1999IncreasedCC,
  title={Increased cytosolic Ca(2+) concentration in endothelial cells by calmodulin antagonists.},
  author={Hiroshi Watanabe and Ryo Takahashi and Qui Kim Tran and Kaoru Takeuchi and Kotoko Kosuge and Hiroko Satoh and Akihiko Uehara and Hiroshi Terada and Hideki Hayashi and Ryuzo Ohno and Kyoichi Ohashi},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={265 3},
  pages={697-702}
}
Many functions of endothelial cells are Ca(2+)/calmodulin dependent, whereas the role of calmodulin in the regulation of cytosolic Ca(2+) ([Ca(2+)](i)) remains largely unexplained. In the present study, effects of various calmodulin antagonists on [Ca(2+)](i) were investigated in cultured aortic endothelial cells loaded with the Ca(2+)-sensitive dye fura-2/AM, and were compared with those of calmodulin-dependent protein kinase II (CaM kinase II) inhibitors. The calmodulin antagonists W-7… CONTINUE READING

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