Increased cyclosporine bioavailability induced by experimental nephrotic syndrome in rats.

@article{Medeiros2007IncreasedCB,
  title={Increased cyclosporine bioavailability induced by experimental nephrotic syndrome in rats.},
  author={Mara Medeiros and Jos{\'e} Trinidad P{\'e}rez-Urizar and Jos{\'e} Pedraza-Chaverri and Ricardo Mu{\~n}oz-Arizpe and Gilberto Casta{\~n}eda-Hern{\'a}ndez},
  journal={Canadian journal of physiology and pharmacology},
  year={2007},
  volume={85 5},
  pages={502-6}
}
Components of whole blood and plasma are highly altered during the presentation of nephrotic syndrome. The present study was aimed to explore the influence of nephrotic syndrome on the pharmacokinetics of cyclosporine (CsA) (10 mg/kg) administered i.v. to control or puromycin-induced nephrotic rats (P-NS). We found an increase in CsA bioavailability in the… CONTINUE READING