Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer.

@article{Kundu2001IncreasedC,
  title={Increased cyclooxygenase-2 (cox-2) expression and activity in a murine model of metastatic breast cancer.},
  author={Namita Kundu and Quanli Yang and Russell Dorsey and Amy M. Fulton},
  journal={International journal of cancer},
  year={2001},
  volume={93 5},
  pages={681-6}
}
Elevated prostaglandin E(2) (PGE(2)) production is a common feature of human malignancies. This activity has often been attributed to increased metabolic activity of the cyclooxygenase enzymes, although a direct comparison of these 2 parameters i.e., prostaglandin production and cox protein expression, is rarely performed in the same malignant tissue. Using a murine model of metastatic breast cancer, we show that PGE(2) levels are positively correlated with increased tumorigenic and metastatic… CONTINUE READING

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