Increased cyclic adenosine monophosphate levels block progression but not initiation of human T cell proliferation.

@article{Lingk1990IncreasedCA,
  title={Increased cyclic adenosine monophosphate levels block progression but not initiation of human T cell proliferation.},
  author={D S Lingk and Marcia A. Chan and Erwin W. Gelfand},
  journal={Journal of immunology},
  year={1990},
  volume={145 2},
  pages={449-55}
}
The involvement of cyclic nucleotides in the regulation of cell growth is well established as are the findings that sustained high levels of intracellular cyclic adenosine monophosphate (cAMP) inhibit ligand-induced lymphocyte proliferation. However, there is considerable controversy concerning the precise role of cAMP in this regard or the target of its action. A number of studies with cAMP analogs or forskolin have implicated the early events after ligand binding as being particularly… CONTINUE READING

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