Increased counteracting effect of eNOS and nNOS on an alpha1-adrenergic rise in total peripheral vascular resistance in spontaneous hypertensive rats.

@article{Berg2005IncreasedCE,
  title={Increased counteracting effect of eNOS and nNOS on an alpha1-adrenergic rise in total peripheral vascular resistance in spontaneous hypertensive rats.},
  author={Torill Berg},
  journal={Cardiovascular research},
  year={2005},
  volume={67 4},
  pages={736-44}
}
OBJECTIVE The hypertension in spontaneous hypertensive rats (SHR) may result from a hyperactive sympathetic nervous system or from insufficient bioactive nitric oxide (NO) due to increased oxidative stress. The present investigation aimed to elucidate the balance between these two systems by studying the ability of NO to oppose an adrenergic rise in total peripheral vascular resistance (TPVR). METHODS In anesthetized, open-chest SHR and normotensive controls (WKY) on a respirator, blood… CONTINUE READING

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