Increased cortical expression of the orexin-1 receptor following permanent middle cerebral artery occlusion in the rat.

@article{Irving2002IncreasedCE,
  title={Increased cortical expression of the orexin-1 receptor following permanent middle cerebral artery occlusion in the rat.},
  author={E. Alexander Irving and David C. Harrison and Adam J. Babbs and A C Mayes and Colin M. Campbell and A Jacqueline Hunter and Neil Upton and Andrew A. Parsons},
  journal={Neuroscience letters},
  year={2002},
  volume={324 1},
  pages={53-6}
}
The orexins (hypocretins) have recently been implicated in neurodegeneration associated with narcolepsy. Therefore, the current study was designed to investigate changes in the expression of prepro-orexin and the orexin receptors, OX1R and OX2R following permanent middle cerebral artery occlusion (MCAO) in the rat. Six and twenty-four hours following MCAO, increased OX1R mRNA and protein expression (as assessed by Western blotting and immunohistochemistry) was detected in the ischaemic cortex… CONTINUE READING