Increased contractility of hepatic stellate cells in cirrhosis is mediated by enhanced Ca2+-dependent and Ca2+-sensitization pathways.

@article{Iizuka2011IncreasedCO,
  title={Increased contractility of hepatic stellate cells in cirrhosis is mediated by enhanced Ca2+-dependent and Ca2+-sensitization pathways.},
  author={Masateru Iizuka and Takahisa Murata and M Hori and Hiroshi Ozaki},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2011},
  volume={300 6},
  pages={
          G1010-21
        }
}
Activation of hepatic stellate cells (HSCs) results in cirrhosis and portal hypertension due to intrahepatic resistance. Activated HSCs increase their contraction after receptor agonist stimulation; however, the signaling pathways for the regulation of contraction are not fully understood. The aim of this study was to elucidate the change in contractile mechanisms of HSCs after cirrhotic activation. The expression pattern of contractile regulatory proteins was analyzed with quantitative RT-PCR… CONTINUE READING

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