Increased connectivity of hub networks and cognitive impairment in multiple sclerosis.

OBJECTIVE To investigate default-mode network (DMN) and frontoparietal network (FPN) dysfunction in cognitively impaired (CI) patients with multiple sclerosis (MS) because these networks strongly relate to cognition and contain most of the hubs of the brain. METHODS Resting-state fMRI and neuropsychological assessments were performed in 322 patients with… (More)

3 Figures & Tables