Increased concentrations of P(i) and lactic acid reduce creatine-stimulated respiration in muscle fibers.

@article{Walsh2002IncreasedCO,
  title={Increased concentrations of P(i) and lactic acid reduce creatine-stimulated respiration in muscle fibers.},
  author={Brandon Walsh and Toomas Tiivel and Michail Tonkonogi and Kent Sahlin},
  journal={Journal of applied physiology},
  year={2002},
  volume={92 6},
  pages={2273-6}
}
We tested the hypothesis that the respiratory function of skeletal muscle mitochondria is impaired by lactic acidosis and elevated concentrations of P(i). The rate of respiration of chemically skinned fiber bundles from rat soleus muscle was measured at [P(i)] (brackets denote concentration) and pH values similar to those at rest (3 mM P(i), pH 7.0) and high-intensity exercise (20 mM P(i), pH 6.6). Respiration was measured in the absence of ADP and after sequential additions of 0.1 mM ADP, 20… CONTINUE READING
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