Increased complexity in carcinomas: Analyzing and modeling the interaction of human cancer cells with their microenvironment.

  title={Increased complexity in carcinomas: Analyzing and modeling the interaction of human cancer cells with their microenvironment.},
  author={Mira Stadler and Stefanie Walter and Angelika Walzl and Nina Kramer and Christine Unger and Martin Scherzer and Daniela Unterleuthner and Markus Hengstschlaeger and Georg Krupitza and Helmut Dolznig},
  journal={Seminars in cancer biology},
Solid cancers are not simple accumulations of malignant tumor cells but rather represent complex organ-like structures. Despite a more chaotic general appearance as compared to the highly organized setup of healthy tissues, cancers still show highly differentiated structures and a close interaction with and dependency on the interwoven connective tissue. This complexity within cancers is not known in detail at the molecular level so far. The first part of this article will shortly describe the… CONTINUE READING

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