Increased colorectal cancer incidence in obligate carriers of heterozygous mutations in MUTYH.

@article{Jones2009IncreasedCC,
  title={Increased colorectal cancer incidence in obligate carriers of heterozygous mutations in MUTYH.},
  author={Natalie C Jones and Stefanie Vogt and Maartje Nielsen and Daria Christian and Petra A Wark and Diana E Eccles and Emma C Edwards and D Gareth R Evans and Eamonn R Maher and Hans F. A. Vasen and Frederik J Hes and Stefan Aretz and Julian R. Sampson},
  journal={Gastroenterology},
  year={2009},
  volume={137 2},
  pages={489-94, 494.e1; quiz 725-6}
}
BACKGROUND & AIMS MUTYH-associated polyposis (MAP) is an autosomal recessive disorder caused by mutations in the MUTYH gene. Patients with MAP are at extremely high risk of colorectal cancer, but the risks of colorectal and other cancers in heterozygous carriers of a single MUTYH mutation are uncertain. We performed a retrospective study of cancer incidence and causes of death among obligate MUTYH heterozygote individuals. METHODS MAP index cases were identified from polyposis registers in… CONTINUE READING