Increased colonization of indwelling medical devices by quorum-sensing mutants of Staphylococcus epidermidis in vivo.

Abstract

Infections with the leading nosocomial pathogen Staphylococcus epidermidis are characterized by biofilm development on indwelling medical devices. We demonstrate that the quorum-sensing regulator agr affects the biofilm development of S. epidermidis in an unexpected fashion and is likely involved in promoting biofilm detachment. An isogenic agr mutant… (More)

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