Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS.

@article{Bajor2015IncreasedCB,
  title={Increased colonic bile acid exposure: a relevant factor for symptoms and treatment in IBS.},
  author={Antal Bajor and Hans T{\"o}rnblom and M Rudling and K A Ung and Magnus Simr{\'e}n},
  journal={Gut},
  year={2015},
  volume={64 1},
  pages={84-92}
}
OBJECTIVE Bile acids may play a role in the pathogenesis of IBS. We investigated the potential effects of bile acids entering the colon and its role in the symptom pattern in IBS. DESIGN We measured 75Se-labelled homocholic acid-taurine (75SeHCAT) retention, and serum levels of 7α-hydroxy-4-cholesten-3-one (C4) and fibroblast growth factor (FGF) 19 in patients with IBS (n=141) and control subjects (75SeHCAT n=29; C4 and FGF19 n=435). In patients with IBS stool frequency and form, as well as… CONTINUE READING
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