Increased collagen type III synthesis by fibroblasts isolated from strictures of patients with Crohn's disease.

@article{Stallmach1992IncreasedCT,
  title={Increased collagen type III synthesis by fibroblasts isolated from strictures of patients with Crohn's disease.},
  author={A Stallmach and Detlef B Schuppan and Hans H. Riese and Heinz Matthes and E. O. Riecken},
  journal={Gastroenterology},
  year={1992},
  volume={102 6},
  pages={1920-9}
}
Increased type III collagen deposition in all layers of the intestinal tract, including the lamina propria, is a common feature of strictures in Crohn's disease. In the present study, it was found that in comparison with fibroblasts from normal or nonstrictured but inflamed intestinal lamina propria, the fibroblasts isolated from strictures of patients with Crohn's disease produce significantly more collagen, especially collagen type III. Transforming growth factor beta 1 (TGF-beta 1… CONTINUE READING