Increased collagen content in insulin-resistant skeletal muscle.

  title={Increased collagen content in insulin-resistant skeletal muscle.},
  author={Rachele Berria and Lishan Wang and Dawn K Richardson and Jean Finlayson and Renata Belfort and Thongchai Pratipanawatr and Elena De Filippis and Sangeeta R. Kashyap and Lawrence J. Mandarino},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={290 3},
Oversupply and underutilization of lipid fuels are widely recognized to be strongly associated with insulin resistance in skeletal muscle. Recent attention has focused on the mechanisms underlying this effect, and defects in mitochondrial function have emerged as a potential player in this scheme. Because evidence indicates that lipid oversupply can produce abnormalities in extracellular matrix composition and matrix changes can affect the function of mitochondria, the present study was… CONTINUE READING