Increased cold allodynia following intrathecal N-methyl-D-aspartate in rats with a mononeuropathy.

@article{Vissers2005IncreasedCA,
  title={Increased cold allodynia following intrathecal N-methyl-D-aspartate in rats with a mononeuropathy.},
  author={Kris Christiaan Vissers and Vincent LH Hoffmann and Hugo F Adriaensen and Ren{\'e} J Heylen and Theo Frans Meert},
  journal={Life sciences},
  year={2005},
  volume={77 4},
  pages={414-22}
}
NMDA receptors are involved in the modulation of neuropathic pain behavior and central sensitization. In vivo, this is mostly demonstrated by the use of specific antagonists such as MK801. Because studies evaluating the direct impact of spinal NMDA in neuropathic pain models are lacking, we performed a series of experiments to study the role of spinal NMDA injection on existing cold allodynia, as a measurement of neuropathic pain behavior in rodents. Intrathecal injection of NMDA resulted in an… CONTINUE READING

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