Increased circulatory levels of lipopolysaccharide (LPS) and zonulin signify novel biomarkers of proinflammation in patients with type 2 diabetes

@article{Jayashree2013IncreasedCL,
  title={Increased circulatory levels of lipopolysaccharide (LPS) and zonulin signify novel biomarkers of proinflammation in patients with type 2 diabetes},
  author={Balasubramanyam Jayashree and Yesodha S Bibin and D Immuanual Gilwax Prabhu and Coimbatore Subramanian Shanthirani and Kuppan Gokulakrishnan and Baddireddi Subhadra Lakshmi and Viswanathan Mohan and Muthuswamy Balasubramanyam},
  journal={Molecular and Cellular Biochemistry},
  year={2013},
  volume={388},
  pages={203-210}
}
Emerging data indicate that gut-derived endotoxin (metabolic endotoxemia) may contribute to low-grade systemic inflammation in insulin-resistant states. Specific gut bacteria seem to serve as lipopolysaccharide (LPS) sources and several reports claim a role for increased intestinal permeability in the genesis of metabolic disorders. Therefore, we investigated the serum levels of LPS and zonulin (ZO-1, a marker of gut permeability) along with systemic levels of tumor necrosis factor-α (TNF… CONTINUE READING
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