Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia.

@article{Yamazaki2002IncreasedCL,
  title={Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia.},
  author={Yuji Yamazaki and Ryo Okazaki and Minako Shibata and Yukihiro Hasegawa and Kohei Satoh and Toshihiro Tajima and Yasuhiro Takeuchi and Toshiro Fujita and Kazuhiko Nakahara and Takeyoshi Yamashita and Seiji Fukumoto},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 11},
  pages={4957-60}
}
Hypophosphatemic rickets/osteomalacia with inappropriately low serum 1,25-dihidroxyvitamin D level is commonly observed in X-linked hypophosphatemic rickets/osteomalacia, autosomal dominant hypophosphatemic rickets/osteomalacia and tumor-induced osteomalacia. Although the involvement of a newly identified factor, FGF-23, in the pathogenesis of ADHR and TIO has been suggested, clinical evidence indicating the role of FGF-23 has been lacking. We have previously shown that FGF-23 is cleaved… CONTINUE READING