Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis.

@article{Peng2013IncreasedCL,
  title={Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis.},
  author={Wenming Peng and Laura Maintz and Jean-Pierre Allam and Ulrike Raap and Ines G{\"u}tgemann and Jutta Kirfel and Eva Wardelmann and Sven Perner and Wei Zhao and Rolf Fimmers and Klaus Walgenbach and Johannes Oldenburg and Lawrence B Schwartz and Natalija Novak},
  journal={Blood},
  year={2013},
  volume={122 10},
  pages={
          1779-88
        }
}
Mastocytosis is a rare heterogeneous disease characterized by increase of mast cells (MCs) in different organs. Neurotrophins (NTs) have been shown to promote differentiation and survival of MCs, which in turn represent a major source of NTs. Thus, a contribution of NTs to mastocytosis seems highly conceivable but has not yet been investigated. We could demonstrate expression of high-affinity NT receptors tropomyosin-related kinase A (TrkA) for nerve growth factor (NGF)-β, TrkB for brain… 

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