Increased circulating follicular regulatory T cells in Hashimoto's thyroiditis.

  title={Increased circulating follicular regulatory T cells in Hashimoto's thyroiditis.},
  author={Jiwei Zhao and Yanxia Chen and Zhenyao Xu and Wei Yang and Zhongliang Zhu and Yingxiang Song and Jinlin Liu},
  volume={51 7},
OBJECTIVE Follicular T helper (Tfh) cells are involved in the pathogenesis of Hashimoto's thyroiditis (HT), while follicular T regulatory (Tfr) cells inhibit Tfh cells, which mediate B cell responses. However, the role of Tfr cells in HT remains unclear. METHODS Forty-six healthy controls (HCs) and 84 HT patients were enrolled in the study. The percentage of Treg cells, CXCR5- Treg cells, and Tfr cells; the Tfr/Tfh ratio; and the percentage of ICOS, PD-1, CTLA-4, CXCR3 and CCR6 in Tfr cells… CONTINUE READING
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