Increased circulating angiotensin-(1–7) protects white adipose tissue against development of a proinflammatory state stimulated by a high-fat diet

@article{Santos2012IncreasedCA,
  title={Increased circulating angiotensin-(1–7) protects white adipose tissue against development of a proinflammatory state stimulated by a high-fat diet},
  author={S{\'e}rgio Henrique de Sousa Santos and Luciana Rodrigues Fernandes and Camila Santos Pereira and Andr{\'e} Luiz Senna Guimar{\~a}es and Alfredo M.B. de Paula and Maria Jos{\'e} Campagnole-Santos and Jacqueline Isaura Alvarez-Leite and Michael Bader and Robson Augusto Souza Santos},
  journal={Regulatory Peptides},
  year={2012},
  volume={178},
  pages={64-70}
}
INTRODUCTION The aim of the present study was to evaluate the effect of a transgenic-induced chronic increase of Ang-(1-7) on the expression of inflammatory markers in adipose tissue and the metabolic profile in rats treated with high-fat diet. RESEARCH DESIGN AND METHODS Transgenic rats expressing an Ang-(1-7)-producing fusion protein (TGR L-3292) and Sprague Dawley (SD) control rats 4 weeks old were treated for 8 weeks with a high-fat diet. Food intake and body weight were measured once a… CONTINUE READING

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Anti-inflammatory effects of the activation of the angiotensin-(1–7) receptor, MAS, in experimental models of arthritis

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