Increased circulating PEDF and low sICAM-1 are associated with sickle cell retinopathy.

@article{Cruz2015IncreasedCP,
  title={Increased circulating PEDF and low sICAM-1 are associated with sickle cell retinopathy.},
  author={Paulo Roberto Silva Cruz and Rodrigo Pessoa Cavalcanti Lira and Sergio Augusto Carvalho Pereira Filho and Branca Dias Batista de Souza and F N Mitsuushi and Farid Menaa and Kleber Yotsumoto Fertrin and Jose PC Vasconcellos and Nicola Conran and Fernando Ferreira Costa and M{\^o}nica Barbosa de Melo},
  journal={Blood cells, molecules & diseases},
  year={2015},
  volume={54 1},
  pages={33-7}
}
Sickle cell retinopathy (SCR) develops in up to 30% of sickle cell disease patients (SCD) during the second decade of life. Treatment for this affection remains palliative, so studies on its pathophysiology may contribute to the future development of novel therapies. SCR is more frequently observed in hemoglobin SC disease and derives from vaso-occlusion in the microvasculature of the retina leading to neovascularization and, eventually, to blindness. Circulating inflammatory cytokines… CONTINUE READING
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