Increased circulating β2-adrenergic receptor autoantibodies are associated with smoking-related emphysema

@article{Hu2017IncreasedC,
  title={Increased circulating $\beta$2-adrenergic receptor autoantibodies are associated with smoking-related emphysema},
  author={Jia-yi Hu and Bei-bei Liu and Yi-peng Du and Yuan Zhang and Yi-wei Zhang and You-yi Zhang and Ming Xu and Bei He},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
Smoking is a dominant risk factor for chronic obstructive pulmonary disease (COPD) and emphysema, but not every smoker develops emphysema. Immune responses in smokers vary. Some autoantibodies have been shown to contribute to the development of emphysema in smokers. β2-adrenergic receptors (β2-ARs) are important targets in COPD therapy. β2-adrenergic receptor autoantibodies (β2-AAbs), which may directly affect β2-ARs, were shown to be increased in rats with passive-smoking-induced emphysema in… 
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