Increased chronic lymphocytic leukemia proliferation upon IgM stimulation is sustained by the upregulation of miR-132 and miR-212.

@article{Tavolaro2015IncreasedCL,
  title={Increased chronic lymphocytic leukemia proliferation upon IgM stimulation is sustained by the upregulation of miR-132 and miR-212.},
  author={Simona Tavolaro and Teresa Colombo and Sabina Chiaretti and Nadia Peragine and Valerio Fulci and Maria Rosaria Ricciardi and Monica Messina and Silvia Bonina and Fulvia Brugnoletti and Marilisa Marinelli and Valeria di Maio and Francesca Romana Mauro and Ilaria Del Giudice and Giuseppe Macino and Robin Fo{\'a} and Anna Rita Guarini},
  journal={Genes, chromosomes & cancer},
  year={2015},
  volume={54 4},
  pages={222-34}
}
To assess the involvement of microRNAs (miRNAs) in B-cell receptor (BCR) stimulation, we first evaluated miRNA profiling following IgM cross-linking in chronic lymphocytic leukemia (CLL) cells and in normal B lymphocytes. Second, we combined miRNA and gene expression data to identify putative miRNA functional networks. miRNA profiling showed distinctive patterns of regulation after stimulation in leukemic versus normal B lymphocytes and identified a differential responsiveness to BCR engagement… CONTINUE READING
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