Increased chromosome mobility facilitates homology search during recombination

  title={Increased chromosome mobility facilitates homology search during recombination},
  author={Judith Min{\'e}-Hattab and R. Rothstein},
  journal={Nature Cell Biology},
  • Judith Miné-Hattab, R. Rothstein
  • Published 2012
  • Biology, Medicine
  • Nature Cell Biology
  • Homologous recombination, an essential process for preserving genomic integrity, uses intact homologous sequences to repair broken chromosomes. To explore the mechanism of homologous pairing in vivo, we tagged two homologous loci in diploid yeast Saccharomyces cerevisiae cells and investigated their dynamic organization in the absence and presence of DNA damage. When neither locus is damaged, homologous loci occupy largely separate regions, exploring only 2.7% of the nuclear volume. Following… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Repair of strand breaks by homologous recombination.
    • 478
    • PDF
    Mechanisms and Regulation of Mitotic Recombination in Saccharomyces cerevisiae
    • 209
    • PDF
    Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System
    • 311
    • PDF
    Functional implications of genome topology
    • 339
    Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis
    • 197
    • Highly Influenced
    Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?
    • 234


    Publications referenced by this paper.