Increased chromosome mobility facilitates homology search during recombination

@article{MinHattab2012IncreasedCM,
  title={Increased chromosome mobility facilitates homology search during recombination},
  author={Judith Min{\'e}-Hattab and Rodney Rothstein},
  journal={Nature Cell Biology},
  year={2012},
  volume={14},
  pages={510-517}
}
Homologous recombination, an essential process for preserving genomic integrity, uses intact homologous sequences to repair broken chromosomes. To explore the mechanism of homologous pairing in vivo, we tagged two homologous loci in diploid yeast Saccharomyces cerevisiae cells and investigated their dynamic organization in the absence and presence of DNA damage. When neither locus is damaged, homologous loci occupy largely separate regions, exploring only 2.7% of the nuclear volume. Following… CONTINUE READING
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