Increased chromatin association of Sp1 in interphase cells by PP2A-mediated dephosphorylations.

@article{Vicart2006IncreasedCA,
  title={Increased chromatin association of Sp1 in interphase cells by PP2A-mediated dephosphorylations.},
  author={Axel Vicart and Tony Lefebvre and Jean Pierre Imbert and Anne Fernandez and Brigitte Kahn-Perl{\`e}s},
  journal={Journal of molecular biology},
  year={2006},
  volume={364 5},
  pages={897-908}
}
Sp1 dephosphorylation by phosphatase 2A is related to sustained cellular proliferation and is illustrated by an enhanced electrophoretic migration shift. This event occurs concurrently with cell-cycle interphase and increases Sp1 transcriptional activity and in vitro affinity for DNA. We show here that dephosphorylated Sp1 is associated with chromatin more tightly than its phosphorylated counterparts from either resting or mitotic cells. Analysis of the expression of Sp1 point mutants and use… CONTINUE READING
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