Increased cholesterol decreases uterine activity: functional effects of cholesterol alteration in pregnant rat myometrium.

@article{Smith2005IncreasedCD,
  title={Increased cholesterol decreases uterine activity: functional effects of cholesterol alteration in pregnant rat myometrium.},
  author={R. D. Smith and Eduard B. Babiychuk and Karen E. Noble and Annette Draeger and Susan Wray},
  journal={American journal of physiology. Cell physiology},
  year={2005},
  volume={288 5},
  pages={
          C982-8
        }
}
Uterine quiescence is essential for successful pregnancy. Cholesterol and triglycerides are markedly increased in pregnancy. Cholesterol is enriched in microdomains of the plasma membrane known as rafts and caveolae. Both lipid rafts and caveolae have been implicated in cellular signaling cascades. The purpose of this work was to investigate whether manipulation of cholesterol content alters uterine contractility. Late pregnancy (19-21 days) rats were humanely euthanized and strips of… 
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Contractility and Calcium Signaling of Human Myometrium Are Profoundly Affected by Cholesterol Manipulation: Implications for Labor?
TLDR
Elevated cholesterol is deleterious to contractility and Ca2+ signaling in human myometrium and could cause difficulties in labor in obese/dyslipidemic women, consistent with their increased cesarean delivery rates.
Hypercholesterolemia impairs oxytocin-induced uterine contractility in late pregnant mouse.
TLDR
The results of the present study suggest that hypercholesterolemia may attenuate the uterotonic action of oxytocin in late pregnancy by causing downregulation of Oxytocin receptors and suppressing the signaling efficacy through GNAQ and RHOA proteins.
Erratum to: Effect of high-fat diet on rat myometrium during pregnancy—isolated myometrial mitochondria are not affected
TLDR
It is found that a previously undescribed subsarcolemmal localization of the mitochondria in the myocyte was identified and no evidence of altered myometrial mitochondrial function or morphology in this animal model of obesity prior to and during pregnancy.
The effects of a high-fat, high-cholesterol diet on markers of uterine contractility during parturition in the rat.
TLDR
A high-fat, high-cholesterol (HFHC) diet significantly increases body weight and alters lipid profiles that correlate with decreases in key markers of uterine contractility.
Maternal age effects on myometrial expression of contractile proteins, uterine gene expression, and contractile activity during labor in the rat
TLDR
YNG laboring rat myometrium seems primed to contract maximally, whereas activity is blunted in OLDER animals and requires stimulation to meet contractile potential, and further work investigating maternal age effects on myometrial function is required.
Gestational and Hormonal Effects on Magnesium Sulfate's Ability to Inhibit Mouse Uterine Contractility.
TLDR
It is concluded that magnesium's actions are influenced by both gestational state and hormones, such that, at least in mice, it is least effective in early gestation with Oxytocin present and most effective at term in the absence of oxytocin.
Gestational and Hormonal Effects on Magnesium Sulfate’s Ability to Inhibit Mouse Uterine Contractility
TLDR
It is concluded that magnesium’s actions are influenced by both gestational state and hormones, such that, at least in mice, it is least effective in early gestation with Oxytocin present and most effective at term in the absence of oxytocin.
Cholesterol depletion alters coronary artery myocyte Ca2+ signalling in a stimulus-specific manner
Additive Inhibitory Effects of Progesterone and Sodium Nitroprusside on Uterine Contractility During Pregnancy
TLDR
Progesterone (P4) and nitric oxide (NO) suppress uterine contractility (CTX) in term, preterm, and nonpregnant tissues, with increased sensitivity in laboring tissues, and the combination of P4 with SNP significantly suppresses CTX.
Poor Spontaneous and Oxytocin-Stimulated Contractility in Human Myometrium from Postdates Pregnancies
TLDR
Myometrium from prolonged pregnancies contracts poorly in vitro even when stimulated with oxytocin and in active labour, and it is shown that postdates pregnancy is associated with poor myometrial activity and suggested that this may contribute to increasedMyometrial quiescence and hence, prolonged gestation.
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