Increased cholesterol decreases uterine activity: functional effects of cholesterol alteration in pregnant rat myometrium.

@article{Smith2005IncreasedCD,
  title={Increased cholesterol decreases uterine activity: functional effects of cholesterol alteration in pregnant rat myometrium.},
  author={Robert D. Smith and Eduard B. Babiychuk and Karen Noble and A Draeger and Susan Wray},
  journal={American journal of physiology. Cell physiology},
  year={2005},
  volume={288 5},
  pages={C982-8}
}
Uterine quiescence is essential for successful pregnancy. Cholesterol and triglycerides are markedly increased in pregnancy. Cholesterol is enriched in microdomains of the plasma membrane known as rafts and caveolae. Both lipid rafts and caveolae have been implicated in cellular signaling cascades. The purpose of this work was to investigate whether manipulation of cholesterol content alters uterine contractility. Late pregnancy (19-21 days) rats were humanely euthanized and strips of… CONTINUE READING
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Calcium signaling, caveolae and human myometrial contractility

  • AJ Kendrick, J Zhang, M Tattersall, L Bricker, S Quenby, S. Wray
  • Proc Physiol Soc C50:
  • 2004
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