Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes.

@article{Brkers2010IncreasedCI,
  title={Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes.},
  author={Nils Br{\"o}kers and Sinja Le-Huu and Sabine Vogel and Yohannes Hagos and D{\"o}rthe Magdalena Katschinski and Malte Christian Kleinschmidt},
  journal={Cancer science},
  year={2010},
  volume={101 1},
  pages={129-36}
}
The hypoxia-inducible factor (HIF) is the master regulator for oxygen-dependent gene expression. The HIF signal transduction pathway can be manipulated by inhibiting the activity of the HIFalpha-regulating prolyl-4-hydroxylase domain (PHD) enzymes. The consequence of inhibiting the PHD activity for chemoresistance was studied. Inhibiting the PHD activity… CONTINUE READING