Increased cerebrospinal fluid levels of neurofilament protein in progressive supranuclear palsy and multiple-system atrophy compared with Parkinson's disease.

@article{Holmberg1998IncreasedCF,
  title={Increased cerebrospinal fluid levels of neurofilament protein in progressive supranuclear palsy and multiple-system atrophy compared with Parkinson's disease.},
  author={Bj{\"o}rn Holmberg and Lars E. Rosengren and J E Karlsson and Bo E A Johnels},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={1998},
  volume={13 1},
  pages={70-7}
}
More reliable tools are needed for the differentiation of Parkinson's disease (PD) from other parkinsonian disorders. The neurofilament protein (NFL) and the glial fibrillary acidic protein (GFAP) are main structural proteins of axons and fibrillary astroglial cells. By using enzyme-linked immunosorbent assays, these proteins were quantified in the cerebrospinal fluid (CSF) of 49 patients referred to the Department of Neurology for diagnostic consideration or treatment of parkinsonism of… CONTINUE READING