Increased cerebrospinal fluid levels of neurotrophin 3 (NT-3) in elderly patients with major depression

Abstract

Neurotrophin 3 (NT-3) is a member of the neurotrophin gene family which supports the survival of specific neurons. NT-3 was shown to prevent the death of adult central noradrenergic neurons in vivo, a neuronal population which is associated with the pathophysiology of major depression. We quantitated CSF levels of NT-3 in elderly patients with major… (More)
DOI: 10.1038/sj.mp.4000743

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