Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis.

@article{Kroth2017IncreasedCF,
  title={Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis.},
  author={Julia Kroth and Dumitru Ciolac and Vinzenz Fleischer and Nabin Koirala and J. Kr{\"a}mer and Muthuraman Muthuraman and Felix Luessi and Stefan Bittner and G. Gonzalez-Escamilla and Frauke Zipp and Sven G. Meuth and Sergiu Groppa},
  journal={Multiple sclerosis},
  year={2017},
  pages={1352458517748474}
}
BACKGROUND Currently, no unequivocal predictors of disease evolution exist in patients with multiple sclerosis (MS). Cortical atrophy measurements are, however, closely associated with cumulative disability. OBJECTIVE Here, we aim to forecast longitudinal magnetic resonance imaging (MRI)-driven cortical atrophy and clinical disability from cerebrospinal fluid (CSF) markers. METHODS We analyzed CSF fractions of albumin and immunoglobulins (Ig) A, G, and M and their CSF to serum quotients… CONTINUE READING